Viglimet 50/850mg Tablet is an anti-diabetic medication containing Vildagliptin and Metformin as active ingredients. It is used to treat type 2 diabetes mellitus when diet, exercise, and Vildagliptin or Metformin alone are not effective.
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Viglimet 50/850mg Tablet is a combination medication that includes Metformin and Vildagliptin, belonging to the group of antidiabetic agents. It is used to treat type 2 diabetes in adult patients whose diabetes cannot be adequately controlled by diet, exercise alone, or other diabetes medications like insulin or sulphonylureas.
Type 2 diabetes is a chronic condition where the body either doesn't produce enough insulin or the produced insulin does not work effectively. Common symptoms of type 2 diabetes include excessive urination, thirst, hunger, fatigue, and blurred vision.
Metformin in Viglimet 50/850mg Tablet works by reducing glucose production in the liver, decreasing intestinal glucose absorption, and enhancing insulin sensitivity to improve peripheral glucose uptake and utilization. Vildagliptin, on the other hand, stimulates the pancreas to produce more insulin and less glucagon, leading to lower blood glucose levels.
During the treatment with Viglimet 50/850mg Tablet, it is essential to follow a regular exercise and diet plan as advised by the doctor to achieve better results.
Before taking Viglimet 50/850mg Tablet, inform your doctor if you have any liver, kidney, or heart problems. The use of Viglimet 50/850mg Tablet during pregnancy should only be done if advised by the doctor, and it is not recommended for breastfeeding women. This medication is not suitable for children and adolescents under 18 years of age, and caution should be exercised when using it in elderly patients (65 years and above).
Consumption of alcohol is not recommended during treatment with Viglimet 50/850mg Tablet since it may increase the risk of lactic acidosis.
Viglimet 50/850mg Tablet is not recommended to be used in pregnancy due to the lack of insufficient information regarding its safety and efficacy. Consult your doctor if you are pregnant or planning a pregnancy before using this medicine.
Viglimet 50/850mg Tablet may pass into breastmilk. This medicine is not recommended while breastfeeding due to the increased risk of low blood sugar levels in your baby. Consult your doctor if you are breastfeeding before using this medicine.
Viglimet 50/850mg Tablet may cause low blood sugar levels and dizziness which may affect your mental alertness. Avoid driving vehicles or operating machines if you experience these symptoms after taking this medicine.
Viglimet 50/850mg Tablet should be used with caution if you have kidney problems as it may increase the risk of lactic acidosis (high levels of lactic acid in the blood). Your doctor may adjust the dose of this medicine or may suggest a suitable alternative based on your condition.
Viglimet 50/850mg Tablet may increase the risk of liver damage. If you have liver problems, your doctor may suggest tests to monitor your liver functions while on treatment with this medicine.
Viglimet 50/850mg Tablet is a combination medication that helps in the management of type 2 diabetes. It contains two active ingredients, Vildagliptin (50 mg) and Metformin (850 mg).
Vildagliptin works by stimulating the pancreas to produce more insulin, which helps in lowering blood sugar levels. It also reduces the amount of glucagon, a hormone that raises blood sugar levels. This combination of actions helps control blood sugar levels after meals.
Metformin, on the other hand, works by reducing the production of glucose in the liver and improving the body's sensitivity to insulin. This helps the body utilize insulin more effectively, which further helps in lowering blood sugar levels.
By working together, Vildagliptin and Metformin play a vital role in controlling blood sugar levels and preventing serious complications of diabetes, such as retinopathy (eyesight loss), nephropathy (kidney damage), neuropathy (nerve damage), diabetic foot ulcers, and delayed wound healing.
Type 2 Diabetes is a condition that causes abnormal fluctuations in blood sugar levels. In type 2 diabetes, the insulin produced by your body cannot be used properly by the cells to convert glucose into energy. Viglimet 50/850mg Tablet effectively reduces blood sugar levels in this condition.
Vildagliptin primarily works by blocking the action of DPP-4 (Dipeptidyl peptidase-4), an enzyme that degrades the incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). By inhibiting DPP-4, vildagliptin increases the levels of GLP-1 and GIP, resulting in elevated fasting and postprandial levels of these hormones. This leads to enhanced insulin production from pancreatic beta cells and decreased glucagon secretion from alpha cells. The increased insulin/glucagon ratio during hyperglycemia results in reduced hepatic glucose production, leading to lower blood sugar levels.
On the other hand, Metformin Hydrochloride, a biguanide class of oral antihyperglycemic medication, has a different mode of action. It reduces both basal and postprandial plasma glucose levels. Unlike sulfonylureas, it does not cause hypoglycemia. Metformin works by reducing hepatic glucose synthesis, decreasing intestinal glucose absorption, and increasing insulin sensitivity. It enhances peripheral glucose uptake and utilization, leading to improved blood sugar control.
Together, vildagliptin and metformin in Viglimet 50/850mg Tablet provide complementary mechanisms of action to effectively manage type 2 diabetes mellitus when diet, exercise, and monotherapy with either vildagliptin or metformin alone are insufficient.
For adults with Type 2 Diabetes Mellitus, the recommended dose of Viglimet 50/850mg Tablet depends on the patient's current dose of Metformin:
For patients with hepatic impairment, including those with a pre-treatment ALT or AST (liver enzymes) >3 times the upper limit of normal, this combination is not recommended.
For children under 18 years of age, Viglimet 50/850mg Tablet is not recommended.
It is essential to take Viglimet 50/850mg Tablet as directed by your physician. The tablet should be taken with or just after food and should be swallowed whole, without crushing or chewing it. The correct dose and duration will be decided by your doctor based on your age and health condition. Do not stop taking Viglimet 50/850mg Tablet without informing your doctor. It is important to follow your doctor's instructions and continue the medication as prescribed for the best results in managing diabetes.
Viglimet 50/850mg Tablet can interact with several drugs and should be used with caution in certain medical conditions. Here are the drug-drug, drug-food, and drug-disease interactions to be aware of:
Drug-Drug Interactions:
Drug-Food Interactions:
Drug-Disease Interactions:
Viglimet 50/850mg Tablet should not be taken in the following situations:
Viglimet 50/850mg Tablet is not recommended for individuals with congestive heart failure or those with acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without coma. Additionally, there have been no studies conducted using the components of this combination. Due to the unknown excretion of Vildagliptin and/or Metformin Hydrochloride in human milk, Viglimet 50/850mg Tablet should not be given to nursing mothers.
Keep away from light and heat in a dry area. Keep out of children's reach.
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