Viglimet 50/850mg Tablet | Anti-Diabetic | Type 2 | Medicine | ePharma
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Viglimet 50/850mg Tablet

Viglimet 50/850mg Tablet is an anti-diabetic medication containing Vildagliptin and Metformin as active ingredients. It is used to treat type 2 diabetes mellitus when diet, exercise, and Vildagliptin or Metformin alone are not effective.


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✅ Description:

Viglimet 50/850mg Tablet is a combination medication that includes Metformin and Vildagliptin, belonging to the group of antidiabetic agents. It is used to treat type 2 diabetes in adult patients whose diabetes cannot be adequately controlled by diet, exercise alone, or other diabetes medications like insulin or sulphonylureas.

Type 2 diabetes is a chronic condition where the body either doesn't produce enough insulin or the produced insulin does not work effectively. Common symptoms of type 2 diabetes include excessive urination, thirst, hunger, fatigue, and blurred vision.

Metformin in Viglimet 50/850mg Tablet works by reducing glucose production in the liver, decreasing intestinal glucose absorption, and enhancing insulin sensitivity to improve peripheral glucose uptake and utilization. Vildagliptin, on the other hand, stimulates the pancreas to produce more insulin and less glucagon, leading to lower blood glucose levels.

During the treatment with Viglimet 50/850mg Tablet, it is essential to follow a regular exercise and diet plan as advised by the doctor to achieve better results.

Before taking Viglimet 50/850mg Tablet, inform your doctor if you have any liver, kidney, or heart problems. The use of Viglimet 50/850mg Tablet during pregnancy should only be done if advised by the doctor, and it is not recommended for breastfeeding women. This medication is not suitable for children and adolescents under 18 years of age, and caution should be exercised when using it in elderly patients (65 years and above).

Safety Advices


Alcohol
UNSAFE

Consumption of alcohol is not recommended during treatment with Viglimet 50/850mg Tablet since it may increase the risk of lactic acidosis.


Pregnancy
CONSULT YOUR DOCTOR

Viglimet 50/850mg Tablet is not recommended to be used in pregnancy due to the lack of insufficient information regarding its safety and efficacy. Consult your doctor if you are pregnant or planning a pregnancy before using this medicine.


Breastfeeding
CONSULT YOUR DOCTOR

Viglimet 50/850mg Tablet may pass into breastmilk. This medicine is not recommended while breastfeeding due to the increased risk of low blood sugar levels in your baby. Consult your doctor if you are breastfeeding before using this medicine.


Driving
CAUTION

Viglimet 50/850mg Tablet may cause low blood sugar levels and dizziness which may affect your mental alertness. Avoid driving vehicles or operating machines if you experience these symptoms after taking this medicine.


Kidney
CONSULT YOUR DOCTOR

Viglimet 50/850mg Tablet should be used with caution if you have kidney problems as it may increase the risk of lactic acidosis (high levels of lactic acid in the blood). Your doctor may adjust the dose of this medicine or may suggest a suitable alternative based on your condition. 


Liver
CONSULT YOUR DOCTOR

Viglimet 50/850mg Tablet may increase the risk of liver damage. If you have liver problems, your doctor may suggest tests to monitor your liver functions while on treatment with this medicine. 

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✔️ Uses of Viglimet 50/850mg Tablet
  • To treat type II diabetes mellitus (whose diabetes cannot be controlled by diet and exercise alone and/or with other medicines used to treat diabetes)
✔️ How does Viglimet 50/850mg Tablet work?

Viglimet 50/850mg Tablet is a combination medication that helps in the management of type 2 diabetes. It contains two active ingredients, Vildagliptin (50 mg) and Metformin (850 mg).

Vildagliptin works by stimulating the pancreas to produce more insulin, which helps in lowering blood sugar levels. It also reduces the amount of glucagon, a hormone that raises blood sugar levels. This combination of actions helps control blood sugar levels after meals.

Metformin, on the other hand, works by reducing the production of glucose in the liver and improving the body's sensitivity to insulin. This helps the body utilize insulin more effectively, which further helps in lowering blood sugar levels.

By working together, Vildagliptin and Metformin play a vital role in controlling blood sugar levels and preventing serious complications of diabetes, such as retinopathy (eyesight loss), nephropathy (kidney damage), neuropathy (nerve damage), diabetic foot ulcers, and delayed wound healing.

✔️ Side Effects of Viglimet 50/850mg Tablet
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach ache
  • Trembling of hands and feet
✔️ Quick Suggestions:
  • Combine the medication with regular exercise and a healthy diet to help lower blood sugar levels.
  • Take the medication with food to reduce the chance of experiencing an upset stomach.
  • Viglimet 50/850mg Tablet has a lower likelihood of causing weight gain and low blood sugar compared to some other diabetes medicines.
  • If you are due to have surgery under a general anesthetic, inform your doctor about your diabetes treatment.
  • Plan your meals by filling half your plate with starchy vegetables, a quarter with proteins, and a quarter with whole grains.
  • Eat at regular intervals and avoid long gaps between meals or snacks.
  • Monitor your blood sugar levels regularly, especially when you experience fluctuations.
  • Engage in at least 150 minutes of moderate-intensity physical activity or 75 minutes of high-intensity exercise weekly.
  • If you need to lose weight, do so gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Opt for whole grain foods and increase the intake of fruits, vegetables, and other fiber-enriched foods while limiting saturated fats found in unhealthy snacks.
  • Manage stress using techniques like mindfulness, as stress can impact blood sugar levels.
  • Choose low-fat dairy products to support a balanced diet.
  • Keep your blood pressure as close to normal (140/90) as possible to reduce the risk of cardiovascular diseases in diabetes patients.
  • If you experience symptoms such as nausea, vomiting, Kussmaul breathing (labored and deep breathing), and generalized weakness, contact your doctor immediately, as these could be signs of lactic acidosis, a rare but serious metabolic complication associated with the medication.
  • Inform your doctor if you experience symptoms such as abdominal pain, fatigue, loss of appetite, darkened urine, or yellowing of the eyes or skin (jaundice), as they may be related to kidney or liver function.
✔️ Indication of Viglimet 50/850mg Tablet

Type 2 Diabetes is a condition that causes abnormal fluctuations in blood sugar levels. In type 2 diabetes, the insulin produced by your body cannot be used properly by the cells to convert glucose into energy. Viglimet 50/850mg Tablet effectively reduces blood sugar levels in this condition.

✔️ Pharmacology

Vildagliptin primarily works by blocking the action of DPP-4 (Dipeptidyl peptidase-4), an enzyme that degrades the incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). By inhibiting DPP-4, vildagliptin increases the levels of GLP-1 and GIP, resulting in elevated fasting and postprandial levels of these hormones. This leads to enhanced insulin production from pancreatic beta cells and decreased glucagon secretion from alpha cells. The increased insulin/glucagon ratio during hyperglycemia results in reduced hepatic glucose production, leading to lower blood sugar levels.

On the other hand, Metformin Hydrochloride, a biguanide class of oral antihyperglycemic medication, has a different mode of action. It reduces both basal and postprandial plasma glucose levels. Unlike sulfonylureas, it does not cause hypoglycemia. Metformin works by reducing hepatic glucose synthesis, decreasing intestinal glucose absorption, and increasing insulin sensitivity. It enhances peripheral glucose uptake and utilization, leading to improved blood sugar control.

Together, vildagliptin and metformin in Viglimet 50/850mg Tablet provide complementary mechanisms of action to effectively manage type 2 diabetes mellitus when diet, exercise, and monotherapy with either vildagliptin or metformin alone are insufficient.

✔️ Dosage & Administration of Viglimet 50/850mg Tablet

For adults with Type 2 Diabetes Mellitus, the recommended dose of Viglimet 50/850mg Tablet depends on the patient's current dose of Metformin:

  • The combination of Vildagliptin & Metformin may be initiated at either 50 mg Vildagliptin / 500 mg Metformin or 50 mg Vildagliptin / 850 mg Metformin twice daily.
  • Take 1 tablet in the morning and the other in the evening.
  • The recommended maximum daily dose is 100 mg Vildagliptin plus 2000 mg Metformin Hydrochloride.

For patients with hepatic impairment, including those with a pre-treatment ALT or AST (liver enzymes) >3 times the upper limit of normal, this combination is not recommended.

For children under 18 years of age, Viglimet 50/850mg Tablet is not recommended.

It is essential to take Viglimet 50/850mg Tablet as directed by your physician. The tablet should be taken with or just after food and should be swallowed whole, without crushing or chewing it. The correct dose and duration will be decided by your doctor based on your age and health condition. Do not stop taking Viglimet 50/850mg Tablet without informing your doctor. It is important to follow your doctor's instructions and continue the medication as prescribed for the best results in managing diabetes.

✔️ Interaction

Viglimet 50/850mg Tablet can interact with several drugs and should be used with caution in certain medical conditions. Here are the drug-drug, drug-food, and drug-disease interactions to be aware of:

Drug-Drug Interactions:

  • Viglimet 50/850mg Tablet can interact with painkillers like aspirin, ibuprofen, and celecoxib, affecting blood sugar control and potentially increasing the risk of hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar).
  • High blood pressure-lowering pills like nifedipine, captopril, enalapril, and lisinopril may interact with Viglimet 50/850mg Tablet, potentially causing fluctuations in blood pressure levels.
  • Thyroid hormones (thyroxine) may also interact with Viglimet 50/850mg Tablet, affecting its efficacy in controlling blood sugar levels.
  • Antacids like cimetidine may reduce the absorption of vildagliptin, leading to a decrease in its effectiveness.

Drug-Food Interactions:

  • Intake of excessive alcoholic beverages while taking Viglimet 50/850mg Tablet can increase the risk of a life-threatening condition known as Lactic Acidosis. Therefore, it is essential to avoid consuming alcoholic beverages with this medication.

Drug-Disease Interactions:

  • People with heart diseases like congestive heart failure and myocardial infarction should use Viglimet 50/850mg Tablet with caution, as it may worsen certain heart conditions.
  • Patients with vitamin B12 deficiency may experience worsening of the deficiency while on Viglimet 50/850mg Tablet treatment.
  • Viglimet 50/850mg Tablet is not recommended for individuals with alcoholism, as it may exacerbate the condition.
✔️ Contraindications

Viglimet 50/850mg Tablet should not be taken in the following situations:

  • Allergy: If you are allergic to vildagliptin, metformin, or any other ingredients present in Viglimet 50/850mg Tablet, avoid its use.
  • Uncontrolled Diabetes: If you have uncontrolled diabetes with symptoms such as nausea, vomiting, diarrhea, rapid weight loss, and signs of lactic acidosis (such as stomach pain, rapid breathing, and sleepiness), do not take Viglimet 50/850mg Tablet.
  • Diabetic Coma: If you are in a diabetic coma due to a sudden rise or drop in blood sugar levels, Viglimet 50/850mg Tablet should not be used.
  • Alcoholism: If you are an alcoholic or consume alcohol excessively on a regular basis, Viglimet 50/850mg Tablet should be avoided.
  • Pre-existing Medical Conditions: If you have pre-existing medical conditions such as kidney or liver disorders, heart disease, or type 1 diabetes, use Viglimet 50/850mg Tablet with caution and as directed by your doctor.
  • Infection or Dehydration: If you have an active infection or are experiencing dehydration, consult your doctor before taking Viglimet 50/850mg Tablet.
  • Surgery or Stress: If you are scheduled for surgery or experiencing stress, inform your doctor before starting Viglimet 50/850mg Tablet.
  • Breastfeeding: If you are breastfeeding, Viglimet 50/850mg Tablet is not recommended, and you should consult your doctor for alternative options.
✔️ Pregnancy & Lactation

Viglimet 50/850mg Tablet is not recommended for individuals with congestive heart failure or those with acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without coma. Additionally, there have been no studies conducted using the components of this combination. Due to the unknown excretion of Vildagliptin and/or Metformin Hydrochloride in human milk, Viglimet 50/850mg Tablet should not be given to nursing mothers.

✔️ Precautions & Warnings
  • Viglimet 50/850mg Tablet should not be used in patients with type 1 diabetes or diabetic ketoacidosis. Some patients may develop lactic acidosis, a rare but serious condition where there is an accumulation of too much lactic acid in the blood, potentially affecting liver and kidney function.
  • Before starting Viglimet 50/850mg Tablet, inform your doctor if you have a history of pancreatitis, kidney disease, or low vitamin B12 levels.
  • When used with insulin, Viglimet 50/850mg Tablet can significantly lower blood sugar levels, leading to hypoglycemia, which can be life-threatening. In such cases, the doctor may adjust the dose of insulin or Viglimet 50/850mg Tablet.
  • Prolonged use of Viglimet 50/850mg Tablet may lower thyroid-stimulating hormone (TSH), so annual TSH check-ups are recommended.
  • In rare cases, a serious skin reaction called bullous pemphigoid may occur, requiring immediate medical attention.
  • Inform your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. Viglimet 50/850mg Tablet may need to be temporarily stopped before the X-ray procedure.
✔️ Storage Conditions

Keep away from light and heat in a dry area. Keep out of children's reach.

Frequently Asked Questions (FAQ)

No. Viglimet 50/850mg Tablet is only prescribed for the treatment of type 2 diabetes also called as 'non-insulin-dependent diabetes'.

Viglimet 50/850mg Tablet is not recommended in patients who recently had heart attack or heart failure or any signs of heart problems such as serious problems with blood circulation or difficulty in breathing. Consult your doctor before taking Viglimet 50/850mg Tablet.

You can take the Viglimet 50/850mg Tablet at any time of the day, before, during or after meals, as told by the doctor. But it's necessary to take it at the usual time every day for the best results.

The effects of Viglimet 50/850mg Tablet can be observed within 1-3 hours after taking it.

The amount of time for which Viglimet 50/850mg Tablet remains active in your body is not known.
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Check our pricing section for Viglimet 50/850mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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